Biology
Physical Growth Mechanism.
Modeling Growth of Cells and other Living Organisms
At this point, the author has published three books about the growth of living organisms, and two articles. The material is based on the physical growth mechanism which the author discovered and researched. It is difficult to comprehend this kind of discoveries, because of the universal nature of this mechanism. Essentially, this growth mechanism presents one of the general laws of Nature that universally governs the development of all living organisms. The results of research confirmed the validity of this hypothesis with regard to growth of cells. The author also collected numerous facts and observations of his own and in the literature, which indicate that this mechanism also governs the evolvement of multicellular organisms and, in fact, all living species. Many facts and observations prove the hypothesis indirectly, but the abundance of such material and the perfect fit of observations into the framework of the discovered physical growth mechanism make the hypothesis very credible. This will be the next phase of research, that is finding the proofs of validity of this physical growth mechanism for multicellular organisms and presenting them in the book, maybe in the second edition of the book "Physics of Growth and Replication".
The reader can refer to the following books.
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1. Yuri K. Shestopaloff, “Growth and Replication of Cells and Other Living Organisms. Physical Mechanisms that Govern Nature’s Evolvement”, AKVY Press, 2009, 82 p.
2. Yuri K. Shestopaloff, “Physics of Growth and Replication. Physical and Geometrical Perspectives on Living Organisms' Development”, AKVY Press, 2010, 174 p. |
Articles on different aspects of this subject have been reviewed and accepted by journals, but at the moment the author does not have bibliographical data for all of them. One articles has been published in "Biophysical Reviews and Letters", another in "International Journal of Biomathematics". Bibliographical data are below.
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1. Yuri K. Shestopaloff, “The Role of Physical and Geometrical Factors in the Growth of Living Organisms”, Biophysical Reviews and Letters, Vol. 5, No. 1 (2010), p. 43–58. DOI No: 10.1142/S1793048010001111
2. Shestopaloff, Yu. K. “A mathematical model of the physical growth mechanism and geometrical characterization of growing forms”, International Journal of Biomathematics, 2011, Vol. 4, No. 1, p. 35-53. DOI: 10.1142/S1793524511001180 |
Downloads:
Electronic version of an article published as "Biophysical Reviews and Letters", Vol. 5, No. 1 (2010), p. 43–58. DOI No: 10.1142/S1793048010001111 © Copyright World Scientific Publishing Company, URL http://www.worldscinet.com/brl/mkt/aims_scope.shtml can be downloaded here.
Software for Modeling Cells' Growth on the Basis of the Physical Growth Mechanism
(Physical Growth Mechanism and Cells' Growth)
The readers willing to explore the mathematical model of growth based on the physical growth mechanism, can use the software application presented below. The package includes all source files and the project's and user's documentation. The package also includes executable, located in the project's Debug directory, so that the readers without programming skills can make computations as well. The form of growing cells and other parameters can be defined by users in the application's configuration file.
This command line software application computes growth dependences for cells that have different geometrical forms, such as disk, sphere, two joined frustum cones, cylinder, cylinder with hemispheres at ends (similar to E. coli's shape). Frustum model can be changed from two cones joined by bases to a cylinder by changing the apex radius in the application's configuration file CellGrConfig.txt that is located in the application’s config directory. User information can be found in the User Manual and the project's Docs directory. If you start the executable shesgr.exe located in the project's Debug directory without a command argument, then it will show terms and how to use the cell growth's application and help commands.
The project uses C++ programming language. Project documentation, sample files, results and graphs are packed into archive .rar file and can be downloaded for legitimate use. You can download, use and change this software based on the Free Software License's terms.